Document Report Card

ID: ALA1146212

Journal: J Med Chem

Title: Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.

Authors: Kim H, Deng L, Xiong X, Hunter WD, Long MC, Pirrung MC.

Abstract: This study was undertaken to identify cellular proteins that bind an orally active natural product insulin mimic. Phage display cloning was used with a biotinylated derivative of this molecule as bait. Among the proteins identified was glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which has recently been shown to affect insulin receptor signaling. Binding data support a role for human GAPDH as another target of the insulin mimic, which could explain its action as a selective insulin receptor modulator.

CiteXplore: 17595071

DOI: 10.1021/jm070437i