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ID: ALA1146248
Journal: Bioorg Med Chem Lett
Title: Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells.
Authors: Hadden MK, Blagg BS.
Abstract: Small molecules based upon natural product dimers that exhibit cytotoxic activity were synthesized and evaluated for their anti-proliferative activity in human breast cancer cell lines. A central isophthalic core structure linking aromatic amines containing 3,5-disubstitutions produced the most active compounds. This series of compounds was found to be more active against the estrogen receptor positive cell line MCF-7 than the estrogen receptor negative cell line, SKBr3.
CiteXplore: 17656092