Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities.

ID: ALA1146312

Journal: Bioorg Med Chem Lett

Title: Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities.

Authors: Tang P, Mamdani F, Hu X, Liu JO, Yu B.

Abstract: Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-alpha-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC(50)=0.078microM) comparable to that of the disaccharide derivative (1).

CiteXplore: 17127060

DOI: 10.1016/j.bmcl.2006.11.032

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