Document Report Card

ID: ALA1146391

Journal: J Nat Prod

Title: Antifungal diterpenoid alkaloids from Delphinium denudatum.

Authors: Atta-ur-Rahman, Nasreen A, Akhtar F, Shekhani MS, Clardy J, Parvez M, Choudhary MI.

Abstract: The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5), and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7). Compounds 1, 3, and 7 have not been isolated from this plant previously. The structures of compounds 1, 3, and 7 were determined through spectral and X-ray diffraction analyses. Compounds 1-3 have shown antifungal activity against a number of human pathogenic fungi.

CiteXplore: 9170290

DOI: 10.1021/np960663n