Iridoids as allelochemicals and DNA polymerase inhibitors.
Basic Information
ID: ALA1146495
Journal: J Nat Prod
Title: Iridoids as allelochemicals and DNA polymerase inhibitors.
Authors: Pungitore CR, Ayub MJ, García M, Borkowski EJ, Sosa ME, Ciuffo G, Giordano OS, Tonn CE.
Abstract: Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a pi-pi charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.
CiteXplore: 15043410
DOI: 10.1021/np030238b
Patent ID: ┄