Document Report Card

ID: ALA1146594

Journal: J Nat Prod

Title: The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.

Authors: Bode HB, Irschik H, Wenzel SC, Reichenbach H, Müller R, Höfle G.

Abstract: The structurally unique leupyrrins A1 (1), A2 (2), B1 (3), B2 (4), C (5), and D (6) were isolated as one of three groups of secondary metabolites from Sorangium cellulosum strains So ce705 and So ce690. An unusually substituted gamma-butyrolactone ring and pyrrole and oxazoline rings are embedded in a nonsymmetric macrodiolide core structure, giving rise to compounds 1-6 as members of a novel class of secondary metabolites. Leupyrrin A1 (1) shows good biological activity against various fungi and eukaryotic cells.

CiteXplore: 14510597

DOI: 10.1021/np030109v