Document Report Card
Basic Information
ID: ALA1146615
Journal: Bioorg Med Chem Lett
Title: Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents.
Authors: Ries UJ, Priepke HW, Hauel NH, Handschuh S, Mihm G, Stassen JM, Wienen W, Nar H.
Abstract: Quinoxalinone derivatives as prototypes of dual thrombin and factor Xa inhibitors have been discovered. Nanomolar inhibition of both coagulation enzymes resulted in very potent antithrombotic activity in vitro.
CiteXplore: 12824021