Basic Information
ID: ALA1146622
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of a novel phenyl substituted sydnone series as potential antitumor agents.
Authors: Dunkley CS, Thoman CJ.
Abstract: A series of compounds containing an N-(4'-substituted-3'-nitrophenyl)sydnone moiety with potential antitumor activity was prepared based on active analogues. The rationale behind the design of these compounds is presented along with the 4-step synthetic route to the derivatives in the 4'-position of the phenyl sydnone framework. Out of the six novel compounds, the 4'-fluoro derivative has an improved activity against all three cell lines as compared to the earlier leads.
CiteXplore: 14611853
DOI: 10.1016/s0960-894x(03)00487-6
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets