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ID: ALA1146623
Journal: Bioorg Med Chem Lett
Title: Two antiviral compounds from the plant Stylogne cauliflora as inhibitors of HCV NS3 protease.
Authors: Hegde VR, Pu H, Patel M, Das PR, Butkiewicz N, Arreaza G, Gullo VP, Chan TM.
Abstract: The 70% aq methanolic extract of the Peruvian plant Stylogne cauliflora was found to contain two novel oligophenolic compounds SCH 644343 (1) and SCH 644342 (2), which were identified as inhibitors of HCV NS3 protease. The structure of 1 and 2 was established based on high-resolution NMR studies. Compound 1 inhibited HCV NS3 protease with an IC(50) of 0.3 microM, while compound 2 showed an IC(50) of 0.8 microM.
CiteXplore: 14611859