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Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists.

Basic Information

ID: ALA1146639

Journal: Bioorg Med Chem Lett

Title: Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists.

Authors: Xiang MA, Chen RH, Demarest KT, Gunnet J, Look R, Hageman W, Murray WV, Combs DW, Rybczynski PJ, Patel M.

Abstract: A series of substituted spirobenzazepines was prepared and evaluated as V(1a) and V(2) dual vasopressin receptor antagonists. Compounds 7p and 7q have been shown to be not only potent inhibitors of vasopressin receptors, but also have exhibited an excellent overall pharmaceutical suitability profile.

CiteXplore: 15149662

DOI: 10.1016/j.bmcl.2004.04.016

Patent ID: