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ID: ALA1146665

Journal: Bioorg Med Chem Lett

Title: 4-Substituted anilides as selective melatonin MT2 receptor agonists.

Authors: Epperson JR, Deskus JA, Gentile AJ, Iben LG, Ryan E, Sarbin NS.

Abstract: A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT(2) binding affinity and MT(2) selectivity of at least 70-fold over the MT(1) receptor. Compound 26 demonstrated full agonism at the MT(2) receptor.

CiteXplore: 15013015

DOI: 10.1016/j.bmcl.2003.11.030