Document Report Card
Basic Information
ID: ALA1146665
Journal: Bioorg Med Chem Lett
Title: 4-Substituted anilides as selective melatonin MT2 receptor agonists.
Authors: Epperson JR, Deskus JA, Gentile AJ, Iben LG, Ryan E, Sarbin NS.
Abstract: A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT(2) binding affinity and MT(2) selectivity of at least 70-fold over the MT(1) receptor. Compound 26 demonstrated full agonism at the MT(2) receptor.
CiteXplore: 15013015