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ID: ALA1146681

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.

Authors: Wu Z, Fraley ME, Bilodeau MT, Kaufman ML, Tasber ES, Balitza AE, Hartman GD, Coll KE, Rickert K, Shipman J, Shi B, Sepp-Lorenzino L, Thomas KA.

Abstract: 3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.

CiteXplore: 15012992

DOI: 10.1016/j.bmcl.2003.12.007