Highly potent PDE4 inhibitors with therapeutic potential.

ID: ALA1146692

Journal: Bioorg Med Chem Lett

Title: Highly potent PDE4 inhibitors with therapeutic potential.

Authors: Ochiai H, Ohtani T, Ishida A, Kusumi K, Kato M, Kohno H, Kishikawa K, Obata T, Nakai H, Toda M.

Abstract: Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

CiteXplore: 14684329

DOI: 10.1016/j.bmcl.2003.09.087

Patent ID: ┄