New orally active PDE4 inhibitors with therapeutic potential.

ID: ALA1146706

Journal: Bioorg Med Chem Lett

Title: New orally active PDE4 inhibitors with therapeutic potential.

Authors: Ochiai H, Ishida A, Ohtani T, Kusumi K, Kishikawa K, Obata T, Nakai H, Toda M.

Abstract: Structural optimization of pyrazolopyridine derivative 2, which is one of the newly discovered chemical leads for PDE4 inhibitors from our in-house library, was carried out successfully. The process of discovery of new orally active PDE4 inhibitors, which are expected to possess therapeutic potential, is presented and their structure-activity relationships are discussed.

CiteXplore: 14684291

DOI: 10.1016/j.bmcl.2003.10.025

Patent ID: ┄