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ID: ALA1146709
Journal: Bioorg Med Chem Lett
Title: Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.
Authors: Ma D, Wu W, Yang G, Li J, Li J, Ye Q.
Abstract: The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.
CiteXplore: 14684295