Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement.

ID: ALA1146710

Journal: Bioorg Med Chem Lett

Title: Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement.

Authors: Leban J, Saeb W, Garcia G, Baumgartner R, Kramer B.

Abstract: A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors.

CiteXplore: 14684297

DOI: 10.1016/j.bmcl.2003.10.021

Patent ID: ┄