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ID: ALA1146711

Journal: Bioorg Med Chem Lett

Title: A facile synthesis of 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, a selective 15-lipoxygenase inhibitor.

Authors: Lin BB, Morita T, Lin YS, Chen HL.

Abstract: A facile method to synthesize 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, in yield of 92%, which showed selective inhibition effect on 15-lipoxygenase(soybean source) at IC(50)=24.2+/-2.7 microM while no inhibition effect was observed at greater than 300 microM on 5-lipoxygenase, lipid peroxidase, phospholipase A(2), protein kinase C, and cyclooxygenase.

CiteXplore: 14684299

DOI: 10.1016/j.bmcl.2003.10.012