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ID: ALA1146712
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl)phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents.
Authors: Sharma VM, Adi Seshu KV, Chandra Sekhar V, Madan S, Vishnu B, Babu PA, Vamsee Krishna C, Sreenu J, Ravi Krishna V, Venkateswarlu A, Rajagopal S, Ajaykumar R, Kumar TS.
Abstract: A new series of [4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl-amines was prepared and tested for its in vitro cytotoxic activity against a panel of 12 human cancer cell lines. Compounds 9, 15, 24 and 31 showed good in vitro activity and were further tested for their in vivo efficacy in the HT-29 human colon adeno carcinoma xenograft model. Compound 9 exhibited promising activity in this model. Dose-response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400mg/kg doses were performed.
CiteXplore: 14684300