Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Basic Information
ID: ALA1146726
Journal: Bioorg Med Chem Lett
Title: Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Authors: Bénard C, Zouhiri F, Normand-Bayle M, Danet M, Desmaële D, Leh H, Mouscadet JF, Mbemba G, Thomas CM, Bonnenfant S, Le Bret M, d'Angelo J.
Abstract: A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-1-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments.
CiteXplore: 15109635
DOI: 10.1016/j.bmcl.2004.03.005
Patent ID: ┄