Document Report Card
Basic Information
ID: ALA1146729
Journal: Bioorg Med Chem Lett
Title: Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents.
Authors: Ishida K, Simizu S, Teruya T, Wierzba MK, Osada H.
Abstract: A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations.
CiteXplore: 15109641