Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo)alkanoic acid esters.

ID: ALA1146738

Journal: Bioorg Med Chem Lett

Title: Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo)alkanoic acid esters.

Authors: Farhanullah, Sil D, Tripathi BK, Srivastava AK, Ram VJ.

Abstract: A series of (3-pyridin-2-yl-thiouriedo)alkanoic acid esters (5a-j) have been synthesized by the reaction of pyridin-2-yl-dithiocarbamic acid methyl ester (2) and amino acid esters (4). Most of the synthesized compounds have been evaluated against glucose-6-phosphatase enzyme but only four compounds (5g-j) displayed significant inhibitory activity of the enzyme.

CiteXplore: 15109654

DOI: 10.1016/j.bmcl.2004.02.079

Patent ID: ┄