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ID: ALA1146742
Journal: Bioorg Med Chem Lett
Title: A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection.
Authors: Borhani DW, Calderwood DJ, Friedman MM, Hirst GC, Li B, Leung AK, McRae B, Ratnofsky S, Ritter K, Waegell W.
Abstract: We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.
CiteXplore: 15109663