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ID: ALA1146771
Journal: Bioorg Med Chem Lett
Title: Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
Authors: Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, Barrish JC.
Abstract: A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described.
CiteXplore: 15125967