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ID: ALA1146774

Journal: Bioorg Med Chem Lett

Title: Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists.

Authors: Xiang MA, Chen RH, Demarest KT, Gunnet J, Look R, Hageman W, Murray WV, Combs DW, Patel M.

Abstract: A novel series of spirobenzazepines was synthesized and evaluated for V1a and V2 receptor antagonist activity. Compounds 8b, 8i, and 8k have shown selective V1a receptor antagonist activity. Compounds 8p and 8q were shown to be dual V1a/V2 receptor antagonists.

CiteXplore: 15125974

DOI: 10.1016/j.bmcl.2004.02.103