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ID: ALA1146789
Journal: Bioorg Med Chem Lett
Title: (+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.
Authors: Dukat M, Taroua M, Dahdouh A, Siripurapu U, Damaj MI, Martin BR, Glennon RA.
Abstract: Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown.
CiteXplore: 15203136