Document Report Card
Basic Information
ID: ALA1146812
Journal: Bioorg Med Chem Lett
Title: Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists.
Authors: Sun LQ, Chen J, Bruce M, Deskus JA, Epperson JR, Takaki K, Johnson G, Iben L, Mahle CD, Ryan E, Xu C.
Abstract: A series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT(1) and MT(2) receptors was determined using 2-[(125)I]-iodomelatonin as the radioligand. From this series of benzoxazole derivatives, compounds 14 and 17 were identified as melatonin receptor agonists.
CiteXplore: 15203165