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ID: ALA1146815
Journal: Bioorg Med Chem Lett
Title: Novel dual inhibitors of calpain and lipid peroxidation.
Authors: Auvin S, Pignol B, Navet E, Pons D, Marin JG, Bigg D, Chabrier PE.
Abstract: A series of molecules with dual inhibitory activities on calpain and lipid peroxidation were synthesized. These hybrid compounds were built on the calpain pharmacophore 2-hydroxytetrahydrofuran linked to a set of antioxidants via a l-leucine linker. Compound 7, the most potent in cellular calpain and lipid peroxidation inhibitions, provided effective protection against glial cell death induced by maitotoxin.
CiteXplore: 15203170