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ID: ALA1146821
Journal: Bioorg Med Chem Lett
Title: Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones.
Authors: Coelho A, Sotelo E, Fraiz N, Yáñez M, Laguna R, Cano E, Raviña E.
Abstract: A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)-pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring.
CiteXplore: 14698150