Document Report Card
Basic Information
ID: ALA1146833
Journal: Bioorg Med Chem Lett
Title: A novel series of potent and selective IKK2 inhibitors.
Authors: Bingham AH, Davenport RJ, Gowers L, Knight RL, Lowe C, Owen DA, Parry DM, Pitt WR.
Abstract: A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.
CiteXplore: 14698170