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ID: ALA1146834
Journal: Bioorg Med Chem Lett
Title: 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Authors: Kunick C, Lauenroth K, Leost M, Meijer L, Lemcke T.
Abstract: Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3beta versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3beta selectivity of 1-azakenpaullone compared to other paullone derivatives.
CiteXplore: 14698171