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ID: ALA1146871
Journal: Bioorg Med Chem Lett
Title: Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists.
Authors: Sasikumar TK, Burnett DA, Zhang H, Smith-Torhan A, Fawzi A, Lachowicz JE.
Abstract: Acylated and aroylated hydrazinoclozapines are highly potent dopamine D(1) antagonists that show remarkable selectivity over other dopamine receptors. The most potent compound in this series is the 2,6-dimethoxybenzhydrazide 33 with a D(1)K(i) of 1.6 nM and 212-fold selectivity over D(2) receptor.
CiteXplore: 16809034