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ID: ALA1146874
Journal: Bioorg Med Chem Lett
Title: Metabolism investigation leading to novel drug design 2: orally active prostacyclin mimetics. Part 5.
Authors: Takamura F, Tanaka A, Takasugi H, Taniguchi K, Nishio M, Seki J, Hattori K.
Abstract: A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI(2) mimetics based on blocking the main metabolic pathway of FK788. The new compound 7c was found to be equipotent to FK788 towards PGI(2) agonist activity and metabolically more stable than FK788.
CiteXplore: 16824754