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ID: ALA1146890

Journal: Bioorg Med Chem Lett

Title: Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors.

Authors: Tully DC, Liu H, Chatterjee AK, Alper PB, Williams JA, Roberts MJ, Mutnick D, Woodmansee DH, Hollenbeck T, Gordon P, Chang J, Tuntland T, Tumanut C, Li J, Harris JL, Karanewsky DS.

Abstract: We report a novel series of noncovalent inhibitors of cathepsin S. The synthesis of the peptidomimetic scaffold is described and structure-activity relationships of P3, P1, and P1' subunits are discussed. Lead optimization to a non-peptidic scaffold has resulted in a new class of potent, highly selective, and orally bioavailable cathepsin S inhibitors.

CiteXplore: 16876407

DOI: 10.1016/j.bmcl.2006.07.032