Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing.
Basic Information
ID: ALA1146894
Journal: Bioorg Med Chem Lett
Title: Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing.
Authors: Kang KS, Kim HY, Yamabe N, Yokozawa T.
Abstract: The activity-guided fractionation of sun ginseng (SG, heat processed Panax ginseng C. A. Meyer at 120 degrees C) was carried out to identify its main active hydroxyl radical (*OH) scavenging components. As a result, the n-BuOH fraction mainly consisting of ginsenosides showed the strongest activity. Of several ginsenosides of SG, the *OH scavenging activities of relatively high contents of 20(S)-Rg(3), 20(R)-Rg(3), Rk(1), and Rg(5) were compared. Rg(5) and 20(S)-Rg(3) showed strong *OH scavenging IC(50) values of 0.15 and 0.44 mM, respectively, and these activities were prominently higher than each of their respective isomers. Therefore, stereospecificity exists in the *OH scavenging activities of ginsenosides produced by heat processing. Especially, the double bond at carbon-20(22) or the OH group at carbon-20 geometrically close to OH at carbon-12 is thought to increase the *OH scavenging activity of ginsenosides.
CiteXplore: 16901695
DOI: 10.1016/j.bmcl.2006.07.071
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