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ID: ALA1146898
Journal: Bioorg Med Chem Lett
Title: Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists.
Authors: Jin G, Wu CC, Tawatao RI, Chan M, Carson DA, Cottam HB.
Abstract: Several 9-benzyl adenine derivatives bearing various substituted amines at the 8-position have been prepared and evaluated for interferon induction in peripheral blood mononuclear cells (PBMC) from healthy human donors. The 8-bromoadenine derivative 5 was used as a versatile intermediate for all substitutions. The most active 8-substituted amino compound was found to be the 8-morpholinoethylamino derivative 19 which had an EC(50) in the submicromolar range.
CiteXplore: 16784848