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ID: ALA1146903
Journal: Bioorg Med Chem Lett
Title: Modification of the clozapine structure by parallel synthesis.
Authors: Su J, Tang H, McKittrick BA, Burnett DA, Zhang H, Smith-Torhan A, Fawzi A, Lachowicz J.
Abstract: A structure-activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D(1)-selective and D(2)-selective compounds can be obtained.
CiteXplore: 16806922