Document Report Card

Basic Information

ID: ALA1146916

Journal: Bioorg Med Chem Lett

Title: Studies towards the conception of new selective PPARbeta/delta ligands.

Authors: Basséne CE, Suzenet F, Hennuyer N, Staels B, Caignard DH, Dacquet C, Renard P, Guillaumet G.

Abstract: In order to define new PPARbeta/delta ligands, SAR study on the selective PPARbeta/delta activator L-165,041 led to the identification of one key functional group for selective PPARbeta/delta activation. Furthermore, taking advantage of SAR studies done elsewhere on the most selective PPARbeta/delta ligand GW501516, the conception of new ligands showing good affinity for PPARbeta/delta is reported. Finally, synthesis and biological evaluation of pyridine analogues have shown the benefical effect of the pyridine ring on the PPARbeta/delta subtype selectivity.

CiteXplore: 16797985

DOI: 10.1016/j.bmcl.2006.06.028