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ID: ALA1146934
Journal: Bioorg Med Chem Lett
Title: Polyhydroxylated 4-thiaflavans as multipotent antioxidants: protective effect on oxidative DNA damage in vitro.
Authors: Lodovici M, Menichetti S, Viglianisi C, Caldini S, Giuliani E.
Abstract: Hydroxylated 4-thiaflavans, possessing the antioxidant features of catechol containing flavonoids and/or tocopherols, were evaluated as protective agents against oxidation damage induced in herring sperm DNA by cumene hydroperoxide (CumOOH) or by the glutathione/ferric ion (GSH/Fe(3+)) system. Our data indicate that the effective protection exerted by some of the tested compounds is overall higher than those provided by catechin and alpha-tocopherol, which might be attributed both to the scavenging properties and chelation of Fe(2+) ions.
CiteXplore: 16458004