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ID: ALA1146935
Journal: Bioorg Med Chem Lett
Title: A novel series of urea-based peptidomimetic calpain inhibitors.
Authors: Sanders ML, Donkor IO.
Abstract: A series of peptide aldehyde derivatives in which the P(2) chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of mu-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for mu-calpain over cathepsin B.
CiteXplore: 16412635