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ID: ALA1146960
Journal: Bioorg Med Chem Lett
Title: Synthesis and anticancer activity of thiosemicarbazones.
Authors: Hu WX, Zhou W, Xia CN, Wen X.
Abstract: Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 microM.
CiteXplore: 16458509