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ID: ALA1146964
Journal: Bioorg Med Chem Lett
Title: Factor VIIa inhibitors: improved pharmacokinetic parameters.
Authors: Kolesnikov A, Rai R, Young WB, Mordenti J, Liu L, Torkelson S, Shrader WD, Leahy EM, Hu H, Gjerstad E, Janc J, Katz BA, Sprengeler PA.
Abstract: Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.
CiteXplore: 16455251