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ID: ALA1146979
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.
Authors: Hammerland LG, Johansson M, Malmström J, Mattsson JP, Minidis AB, Nilsson K, Peterson A, Wensbo D, Wållberg A, Osterlund K.
Abstract: Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.
CiteXplore: 16481165