Synthesis and SAR studies of diarylpyrrole anticoccidial agents.
Basic Information
ID: ALA1147009
Journal: Bioorg Med Chem Lett
Title: Synthesis and SAR studies of diarylpyrrole anticoccidial agents.
Authors: Qian X, Liang GB, Feng D, Fisher M, Crumley T, Rattray S, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T.
Abstract: 2-(4-Fluorophenyl)-3-(4-pyridinyl)-5-substituted pyrroles were prepared and evaluated as anticoccidial agents in both in vitro and in vivo assays. Among the compounds evaluated, the dimethylamine-substituted pyrrole 19a is the most potent inhibitor of Eimeria tenella PKG (cGMP-dependent protein kinase). Further SAR studies on the side chain of the 2-pyrrolidine nitrogen did not enhance in vivo anticoccidial activity.
CiteXplore: 16517161
DOI: 10.1016/j.bmcl.2006.01.041
Patent ID: ┄