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ID: ALA1147208
Journal: Eur J Med Chem
Title: Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors.
Authors: Jung JY, Jung SH, Koh HY.
Abstract: The asymmetric synthesis of chiral piperazinylpropylisoxazoline analogues, (R)-(+)-1, 2 and (S)-(-)-1, 2 was accomplished through a seven-step sequence of reactions, which involved asymmetric 1,3-dipolar cycloaddition, alkyl chain extension, and reductive amination as key reactions. Chiral ligands (R)-(+)-1, 2 exhibited the higher binding affinity and selectivity for the D(3) receptor over the D(4) receptor than (S)-(-)-1, 2 ligands.
CiteXplore: 17316913