Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring.

ID: ALA1147210

Journal: Eur J Med Chem

Title: Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring.

Authors: Foroumadi A, Emami S, Mansouri S, Javidnia A, Saeid-Adeli N, Shirazi FH, Shafiee A.

Abstract: A number of levofloxacin analogues carrying a 2-aryl-2-oxoethyl or a 2-aryl-2-oxyiminoethyl moiety attached to the piperazine ring at C-10 position have been prepared and evaluated as antibacterial agents against a series of Gram-positive and Gram-negative bacteria. Some of them exhibited significant inhibitory activity against Gram-positive bacteria.

CiteXplore: 17316916

DOI: 10.1016/j.ejmech.2006.12.034

Patent ID: ┄