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ID: ALA1147412
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues.
Authors: Kim YB, Kim YH, Park JY, Kim SK.
Abstract: Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 microg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.
CiteXplore: 14698199