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ID: ALA1147427
Journal: Bioorg Med Chem Lett
Title: 2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor.
Authors: Nihei K, Yamagiwa Y, Kamikawa T, Kubo I.
Abstract: Chamaecin (2-hydroxy-4-isopropylbenzaldehyde) was synthesized and tested for its tyrosinase inhibitory activity. It partially inhibits the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase with an IC(50) of 2.3 microM. The inhibition kinetics analyzed by Dixon plots found that chamaecin is a mixed type inhibitor. This inhibition may come in part from its ability to form a Schiff base with a primary amino group in the enzyme.
CiteXplore: 14741268