Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry.

ID: ALA1147429

Journal: Bioorg Med Chem Lett

Title: Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry.

Authors: He Y, Yang J, Wu B, Robinson D, Sprankle K, Kung PP, Lowery K, Mohan V, Hofstadler S, Swayze EE, Griffey R.

Abstract: A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.

CiteXplore: 14741271

DOI: 10.1016/j.bmcl.2003.11.031

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