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ID: ALA1147430
Journal: Bioorg Med Chem Lett
Title: Inhibition of alpha-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion.
Authors: Han MS, Oh DJ, Kim DH.
Abstract: We have demonstrated that thiol-bearing analogues of alpha-chymotrysin (alpha-CT) substrates such as (S)-(1-benzyl-2-thiolethyl)-carbamic acid, benzyl ester (3) inhibits alpha-CT, a prototypical serine protease, in the presence of Zn(II) ion. They constitute a novel class of small molecule inhibitors for alpha-CT believed to inhibit the enzyme by forming a ternary complex consisting of alpha-CT, Zn(II) ion, and the inhibitor.
CiteXplore: 14741272