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ID: ALA1147433
Journal: Bioorg Med Chem Lett
Title: Design of small molecule ketoamide-based inhibitors of cathepsin K.
Authors: Catalano JG, Deaton DN, Long ST, McFadyen RB, Miller LR, Payne JA, Wells-Knecht KJ, Wright LL.
Abstract: A novel series of ketoamide-based inhibitors of cathepsin K has been identified. Modifications to P(2) and P(3) elements were crucial to enhancing inhibitory activity. Although not optimized, a selected inhibitor was effective in attenuating type I collagen hydrolysis in a surrogate assay of bone resorption.
CiteXplore: 14741275